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DNA Alkylator/Crosslinker

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DNA Alkylator/Crosslinker

Chemical Structure Cat. No. Product Name CAS No.
Evofosfamide Chemical Structure
BCP06074 Evofosfamide 918633-87-1
Evofosfamide is a potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.
CEP-40125 Chemical Structure
BCP30791 CEP-40125 1456608-94-8
CEP-40125, also known as RXDX-107, is a DNA alkylating drug potentially for the treatment of advanced solid tumours.
Calicheamicin Chemical Structure
BCP30641 Calicheamicin 108212-75-5
Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
Ifosfamide Chemical Structure
BCP06596 Ifosfamide 3778-73-2
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
Nimustine hydrochloride Chemical Structure
BCP11668 Nimustine hydrochloride 55661-38-6
Nimustine hydrochloride is a DNA alkylator and cross-linker. Anticancer agent used to treat malignant glioma. Cardiovascular teratogenicity was studied in rat fetuses.
Carmustine Chemical Structure
BCP27690 Carmustine 154-93-8
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
Ethyleneimine Chemical Structure
BCP29842 Ethyleneimine 151-56-4
Ethyleneimine is a monofunctional alkylating agent with potential antineoplastic activity.
BN-2629 Chemical Structure
BCP20924 BN-2629 232931-57-6
BN-2629 is a DNA-intercalating agent potentially for the treatment of ovarian cancer and leukemia.
SPDP Chemical Structure
BCP21722 SPDP 68181-17-9
SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls.
Disuccinimidyl suberate Chemical Structure
BCP29489 Disuccinimidyl suberate 68528-80-3
DSS crosslinker, or Disuccinimidyl suberate, is a homobifunctional crosslinker that is cell membrane permeable.
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