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DNA Alkylator/Crosslinker

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DNA Alkylator/Crosslinker

Chemical Structure Cat. No. Product Name CAS No.
Melphalan Hydrochloride Chemical Structure
BCP33593 Melphalan Hydrochloride 3223-07-2
Melphalan is an orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.
Treosulfa Chemical Structure
BCP31509 Treosulfa 299-75-2
Treosulfan is an alkylating agent with activity in ovarian cancer and other solid tumor types.
Cyano Temozolomide Chemical Structure
BCP22927 Cyano Temozolomide 287964-59-4
Temozolomide is an oral DNA alkylating agent used to treat some brain cancers.
Evofosfamide Chemical Structure
BCP06074 Evofosfamide 918633-87-1
Evofosfamide is a potent and selective hypoxia-activated phosphoramidate DNA cross-linking mustard; selectively potent under hypoxia and stable to liver microsomes; inhibits H246 cells and HT29 cells with IC50 of 0.1 uM and 0.2 uM respectively; active in an in vivo MIA PaCa-2 pancreatic cancer orthotopic xenograft model.
CEP-40125 Chemical Structure
BCP30791 CEP-40125 1456608-94-8
CEP-40125, also known as RXDX-107, is a DNA alkylating drug potentially for the treatment of advanced solid tumours.
Calicheamicin Chemical Structure
BCP30641 Calicheamicin 108212-75-5
Calicheamicin is a cytotoxic agent that causes double-strand DNA breaks.
Ifosfamide Chemical Structure
BCP06596 Ifosfamide 3778-73-2
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
Nimustine hydrochloride Chemical Structure
BCP11668 Nimustine hydrochloride 55661-38-6
Nimustine hydrochloride is a DNA alkylator and cross-linker. Anticancer agent used to treat malignant glioma. Cardiovascular teratogenicity was studied in rat fetuses.
Carmustine Chemical Structure
BCP27690 Carmustine 154-93-8
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
Ethyleneimine Chemical Structure
BCP29842 Ethyleneimine 151-56-4
Ethyleneimine is a monofunctional alkylating agent with potential antineoplastic activity.
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