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GPCR/G Protein

Chemical Structure Cat. No. Product Name CAS No.
BI-2493 Chemical Structure
 BCP49649 BI-2493 2937344-16-4
BI-2493 is a structural analogue of BI-2865 that was optimized for in vivo administration.
RAS-IN-2 Chemical Structure
 BCP49648 RAS-IN-2 2765081-21-6
RAS-IN-2 (RMC-6236) is a potent pan-KRAS inhibitor targeting activation-state KRAS for cancer-related studies.
Azelaprag Chemical Structure
 BCP49627 Azelaprag 2049980-18-7
Azelaprag is an apelin receptor agonist agent candidate.
GPR81 agonist 1 Chemical Structure
 BCP36389 GPR81 agonist 1 1620992-67-7
GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively.
Lotiglipron Chemical Structure
 BCP49606 Lotiglipron 2401892-75-7
Lotiglipron (PF-07081532) is a Glucagon-like peptide 1 receptor (GLP-1R) agonist in development for the treatment of Diabetes Mellitus-Type 2 and Obesity.
BI-0474 Chemical Structure
 BCP49602 BI-0474 2750570-55-7
BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.
BI-2865 Chemical Structure
 BCP49601 BI-2865 2937327-93-8
BI-2865 is a pan-KRAS inhibitor. BI-2865 inhibited the proliferation of isogenic G12C, G12D or G12V mutant KRAS expressing BaF3 cells more potently than precursor 1 with a mean IC50 of roughly 140 nM.
Efocipegtrutide Chemical Structure
 BCP49526 Efocipegtrutide 2513399-19-2
Efocipegtrutide is a long-acting glucagon, gastric inhibitory peptide (GIP) and glucagon-like peptide-1 (GLP-1) triple full agonist chemically conjugated with constant region of human immunoglobulin via non-peptidyl flexible linker.
Cotadutide Chemical Structure
 BCP49521 Cotadutide 1686108-82-6
Cotadutide is a subcutaneous GLP-1 and glucagon receptor dual agonist that can be used to treat type 2 diabetes.
CVL-871 Chemical Structure
 BCP49405 CVL-871 CVL-871
CVL 871 is a selective partial agonist of the dopamine D1 and D5 receptors.
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