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HCV Protease

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HCV Protease

结构式 货号 产品名称 CAS号
U 18666A 结构式
BCP41254 U 18666A 3039-71-2
U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-lanosterol cyclase activity. U 18666A also acts as a weak inhibitor of hedgehog (Hh) signaling. It has been shown to reduce serum sterol levels in rats in vivo.
IDX 320 结构式
BCP34858 IDX 320 1251165-81-7
IDX320 is a potent non-covalent macrocyclic inhibitor of the HCV NS3/4A protease.
Grazoprevir potassium 结构式
BCP34806 格佐匹韦钾盐 1206524-86-8
Grazoprevir potassium is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
Boceprevir D9 结构式
BCP21353 Boceprevir D9 1256751-11-7
Beclabuvir 结构式
BCP11013 Beclabuvir 958002-33-0
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM.
MK-4882 结构式
BCP13058 MK-4882 1246472-08-1
MK-4882 is a potent HCV NS5A inhibitor.
Elbasvir 结构式
BCP29961 依巴司韦 1370468-36-2
Elbasvir (MK-8742) is a hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitor with EC50s of 4, 3 and 3 nM against genotype 1a, 1b, and 2a, respectively.
Faldaprevir 结构式
BCP27809 Faldaprevir 801283-95-4
Faldaprevir, also known as BI-201335, is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection.
Sovaprevir 结构式
BCP28074 Sovaprevir 1001667-23-7
Sovaprevir is a nonstructural 3 (NS3) protease inhibitor potentially for the treatment of HCV infection
MK-5172 结构式
BCP28567 MK-5172 1350514-68-9
MK-5172 is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Ki of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
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