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HIF

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HIF

Chemical Structure Cat. No. Product Name CAS No.
Enarodustat Chemical Structure
BCP39690 Enarodustat 1262132-81-9
Enarodustat (JTZ-951) exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition.
HIF-2a Translation Inhibitor 76 Chemical Structure
BCP38668 HIF-2a Translation Inhibitor 76 882268-69-1
HIF-2a Translation Inhibitor 76 is a cell-permeable HIF-2a translation inhibitor (IC50 value 5 µM).
TP0463518 Chemical Structure
BCP38229 TP0463518 1558021-37-0
TP0463518 is a novel prolyl hydroxylase (PHD) 1/2/3 pan inhibitor, inducing erythropoietin (EPO) production in both the kidney and liver, increasing the HIF-2α and EPO mRNA expression levels in the kidney cortex.
HS-1793 Chemical Structure
BCP37847 HS-1793 927885-00-5
HS-1793, inhibits hypoxia-induced HIF-1α and VEGF expression, and migration in human prostate cancer cells.
HIF2α-IN-2 Chemical Structure
BCP37538 HIF2α-IN-2 1672666-82-8
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
Rac-PT2399 Chemical Structure
BCP35881 Rac-PT2399 1672662-07-5
(Rac)-PT2399, the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM.
Acetyl-11-keto-beta-boswellic acid Chemical Structure
BCP35036 Acetyl-11-keto-beta-boswellic acid 67416-61-9
Acetyl-11-keto-beta-boswellic acid is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
Acriflavine hydrochloride Chemical Structure
BCP34400 Acriflavine hydrochloride 8063-24-9
Acriflavine is an topical antiseptic agent and has also been used for the treatment of external fungal infections.
SYP-5 Chemical Structure
BCP34132 SYP-5 1384268-04-5
SYP-5 is a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis.
PT2399 Chemical Structure
BCP25901 PT2399 1672662-14-4
PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo.
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