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HIF

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HIF

Chemical Structure Cat. No. Product Name CAS No.
Desidustat Chemical Structure
BCP29692 Desidustat 1616690-16-4
Desidustat is an inhibitor of HIF hydroxylase extracted from patent WO 2014102818 A1, compound example 2.
TP0463518 Chemical Structure
BCP29564 TP0463518 1558021-37-6
TP0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
BAY 87-2243 hydrochloride Chemical Structure
BCP29477 BAY 87-2243 hydrochloride 1227158-86-2
BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I.
VH-298 Chemical Structure
BCP20719 VH-298 2097381-85-4
VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology.
IOX4 Chemical Structure
BCP29069 IOX4 1154097-71-8
IOX4 is a potent inhibitor of PHD2 (IC50 = 1.6 nM).
YC-1 Chemical Structure
BCP09072 YC-1 170632-47-0
YC-1(Lificiguat) is a soluble guanylyl cyclase(sGC) activator; binds to the heme-containing domain of the β subunit with Kd value of 0.6-1.1 μM in the presence of CO.
Glucosamine Chemical Structure
BCP15505 Glucosamine 3416-24-8
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.
Hydralazine hydrochloride Chemical Structure
BCP06289 Hydralazine hydrochloride 304-20-1
Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.
OTAVA-BB Chemical Structure
BCP20646 OTAVA-BB 934593-90-5
LW6 is a novel HIF-1 inhibitor with an IC50 of 4.4 μM.
JNJ-42041935 Chemical Structure
BCP16311 JNJ-42041935 1193383-09-3
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
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