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HSP

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HSP

结构式 货号 产品名称 CAS号
Shepherdin 结构式
BCP42633 Shepherdin 861224-28-4
Shepherdin makes extensive contacts with the ATP pocket of Hsp90, destabilizes its client proteins, and induces massive death of tumor cells by apoptotic and nonapoptotic mechanisms.
DTHIB 结构式
BCP40269 DTHIB 897326-30-6
DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM.
Retaspimycin hydrochloride 结构式
BCP36508 瑞他霉素盐酸盐 857402-63-2
Retaspimycin Hydrochloride is a potent and water-soluble inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9.
Tamoxifen 结构式
BCP33248 他莫昔芬 10540-29-1
Tamoxifen is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen activates autophagy and induces apoptosis.
JG98 结构式
BCP31061 JG98 1456551-16-8
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction.
Alvespimycin HCl 结构式
BCP22705 阿螺旋霉素盐酸盐 467214-21-7
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with EC50 of 62±29 nM.
Debio 0932 结构式
BCP27980 Debio 0932 1061318-81-7
Debio 0932 is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively.
TRC 051384 结构式
BCP29281 TRC 051384 867164-40-7
TRC051384 is a heat shock protein 70 (HSP70) inducer.
TAS-116 结构式
BCP25132 TAS-116 1260533-36-5
TAS-116 is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94. TAS-116 demonstrates less ocular toxicity.
3-Methyltoxoflavin 结构式
BCP30844 3-Methyltoxoflavin 32502-62-8
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.
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