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NFκB

Chemical Structure Cat. No. Product Name CAS No.
Hoipin-1 Chemical Structure
 BCP43940 Hoipin-1 JTP-0819958
HOIPIN-1 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM.
Lipoteichoic acid Chemical Structure
 BCP43680 Lipoteichoic acid 56411-57-5
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways, also used as adjuvant.
JNJ-67856633 Chemical Structure
 BCP43413 JNJ-67856633 2230273-76-2
JNJ-67856633 is novel, first-in-Class MALT1 Protease Inhibitor for the Treatment of B Cell Lymphomas.
IT-603 Chemical Structure
 BCP43206 IT-603 292168-90-2
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603. IT-603 is a NF-κB family member c-Rel inhibitor with an IC50 of 3 μM in electrophoretic mobility shift assay (EMSA).
TBK1/IKKε-IN-5 Chemical Structure
 BCP43331 TBK1/IKKε-IN-5 1893397-65-3
TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
ACHP Chemical Structure
 BCP41504 ACHP 406208-42-2
ACHP is an IκB kinase inhibitor that inhibits DNA binding activity of NF-κB, blocks NF-κB pathway in multiple myeloma cell lines, and induces cell growth arrest and apoptosis.
UCB-9260 Chemical Structure
 BCP40717 UCB-9260 1515888-53-5
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer.
NF-κB-IN-1 Chemical Structure
 BCP40303 NF-κB-IN-1 1227098-15-8
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor.
NK-252 Chemical Structure
 BCP38773 NK-252 1414963-82-8
NK 252 is a Nrf2 activator. It can induce expression of an antioxidant response element promoter driven reporter gene.
Arimoclomol maleate Chemical Structure
 BCP38423 Arimoclomol maleate 289893-26-1
Arimoclomol is a heat shock protein amplifier. It has been granted Fast Track designation by FDA for the treatment of myotrophic lateral sclerosis (ALS).
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