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p53

结构式 货号 产品名称 CAS号
CP-31398 dihydrochloride 结构式
BCP43517 CP-31398 dihydrochloride 1217195-61-3
CP-31398 dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
PK11007 结构式
BCP32609 PK11007 874146-69-7
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
(−)-Nutlin-3 结构式
BCP29278 (−)-Nutlin-3 548472-68-0
Nutlin 3 is a commercial available p53-MDM2 inhibitor, with Ki of 90 nM.
PK11007 结构式
BCP30143 PK11007 38275-34-2
PK11007 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
Pifithrin-β hydrobromide 结构式
BCP17578 环状抑制剂-Α氢溴酸盐 511296-88-1
Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
CP 31398 结构式
BCP14611 CP 31398 259199-65-0
CP 31398 dihydrochloride is a potent activator of p53 with maximum tolerated dose of 400 ppm.
CBL0137 结构式
BCP29977 CBL 0137 1197996-80-7
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM.
Prima-1 结构式
BCP26191 Prima-1 5608-24-2
Prima-1 is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner.
COTI-2 结构式
BCP28961 COTI-2 1039455-84-9
COTI-2 is a small molecule candidate anti-cancer drug which can convert mutant p53 to wild-type conformation.
NSC319726 结构式
BCP28106 NSC319726 71555-25-4
NSC319726 is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.
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