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PAK

结构式 货号 产品名称 CAS号
IPA-3 结构式
BCP42390 IPA-3 42521-82-4
IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
beta-Elemene 结构式
BCP31326 榄香烯 33880-83-0
beta-Elemene is an inhibitor of Pak1 activation, and an anti-cancer ingredient isolated from the Chinese traditional herb Curcuma wenyujin.
FTY720 Acetic Acid Hydrochloride 结构式
BCP31238 FTY720 Acetic Acid Hydrochloride 1346598-36-4
FTY720 is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.
KPT9274 结构式
BCP10637 KPT9274 1643913-93-2
PAK4-IN-1 is an inhibitor of p21-activated kinases (PAKs), with IC50 of ≤100 nM in MTT assay.
NVS-PAK1-1 结构式
BCP29548 NVS-PAK1-1 1783816-74-9
NVS-PAK1-1 is a a specific allosteric PAK1 inhibitor.
FRAX597 结构式
BCP12649 FRAX597 1286739-19-2
FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).
FRAX-1036 结构式
BCP20209 FRAX-1036 1432908-05-8
FRAX1036 is a novel ATP-competitive small molecule inhibitor of group I p21-activated Kinases (PAKs).
5-Aminosalicylic acid 结构式
BCP05326 5-氨基水杨酸 89-57-6
5-Aminosalicylic acid is an anti-inflammatory compound.
FRAX486 结构式
BCP13764 FRAX486 1232030-35-1
FRAX486 is a selective inhibitor of group I PAKs with IC50s of 8.25/39.5, /55.3 nM for PAK1/PAK2/PAK3 respectivelt; less potent for PAK4(IC50=779 nM).
Fingolimod 结构式
BCP05969 芬戈莫德 162359-55-9
Fingolimod(FTY720 free base) is a S1P antagonist with IC50 of 0.033 nM.
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