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Phosphatase

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Phosphatase

结构式 货号 产品名称 CAS号
PRL-3 Inhibitor I 结构式
BCP43976 PRL-3 Inhibitor I 893449-38-2
PRL-3 Inhibitor I is a PRL-3 inhibitor which blocks the migration and invasion of metastatic cancer cells.
Razuprotafib sodium 结构式
BCP44002 Razuprotafib sodium 1809275-69-1
Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inhibitor.
AQX-016A 结构式
BCP37898 AQX-016A 849669-54-1
AQX-016A is a potent activator of SHIP-1 that induces apoptosis of the cancer cell lines in vitro in both a time and dose dependant manner.
DPM-1001 结构式
BCP36902 DPM-1001 1471172-27-6
DPM-1001 is a potent, specific, non-competitive, and orally bioavailable inhibitor of PTP1B, displaying antidiabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity.
ZLDI-8 结构式
BCP36163 ZLDI-8 667880-38-8
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor.
Rbin-1 结构式
BCP36074 Rbin-1 328023-11-6
Rbin-1 is a novel eukaryotic ribosome assembly inhibitor.
IACS-13909 结构式
BCP35927 IACS-13909 2160546-07-4
IACS-13909 is a specific and potent allosteric inhibitor of SHP2 that suppresses the signaling of RTK/MAPK pathway and overcomes multiple mechanisms underlying osimertinib resistance.
BCI 结构式
BCP35766 BCI 1245792-51-1
BCI is an allosteric inhibitor of dual specificity phosphatase (DUSP). BCI specifically inhibits DUSP6 and DUSP1 with EC50s of 13.3 and 8.0 μM in cells, respectively. BCI does not inhibit DUSP5.
SC-43 结构式
BCP33951 SC-43 1400989-25-4
SC-43 is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1) that inactivates STAT3 and reduces liver fibrosis.
TNO155 结构式
BCP33299 TNO155 1801765-04-7
TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors.
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