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结构式 货号 产品名称 CAS号
BLZ945 结构式
BCP14029 BLZ945 953769-46-5
BLZ945 is a brain-penetrant CSF-1R inhibitor. The biochemical IC50 for CSF-1R is 1 nM, which is >3200-fold higher than its affinity for other kinases.
Belnacasan 结构式
BCP02893 贝尔纳卡桑 273404-37-8
Belnacasan (VX-765) is an orally absorbed prodrug of VRT-043198, which exhibits potent inhibition against ICE/caspase-1 and caspase-4 with Ki of 0.8 nM and less than 0.6 nM, respectively.
Linerixibat 结构式
BCP17155 Linerixibat 1345982-69-5
GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) .
2-Aminomethyl-18-crown-6 结构式
BCP49005 2-氨基甲基-18-冠-6 83585-61-9
K-selectride 结构式
BCP24760 三异丁基硼氢化钾 54575-49-4
A-769662 结构式
BCP01873 A-769662 844499-71-4
A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 μM) that displays selectivity towards β1 subunit-containing heterotrimers.
Purmorphamine 结构式
BCP03687 嘌呤胺 483367-10-8
Purmorphamine is an activator of Smoothened, and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
Cabazitaxel 结构式
BCP27641 卡巴他赛 183133-96-2
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
Nicotinamide Riboside 结构式
BCP06938 烟酰胺核糖 1341-23-7
Nicotinamide riboside is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
Momelotinib 结构式
BCP02328 莫洛替尼 1056634-68-4
Momelotinib, also known as CYT387, is an inhibitor of Janus kinases JAK1 and JAK2, acting as an ATP competitor with IC50 values of 11 and 18 nM, respectively. The inhibitor is significantly less active towards other kinases, including JAK3 (IC50 = 0.16 μM). As of 2011, CYT387 is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. Additional potential treatment indications for CYT387 include other myeloproliferative neoplasms, cancer (solid and liquid tumors) and inflammatory conditions.
Bevacizumab 结构式
BCP07998 贝伐珠单抗 216974-75-3
Bevacizumab is a recombinant humanized monoclonal antibody that blocks angiogenesis by inhibiting vascular endothelial growth factor A (VEGF-A).
Delamanid 结构式
BCP07838 德拉马尼 681492-22-8
Delamanid, a newer mycobacterial cell wall synthesis inhibitor, inhibits the synthesisi of mucolic acids, cruciala component of the cell wall of the Mycobacterium tuberculosis complex.
GS441524 结构式
BCP35590 GS441524 1191237-69-0
GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir]. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent. GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a coronavirus that only infects cats.
D-Luciferin k Salt 结构式
BCP08298 D-荧光素钾盐 115144-35-9
D-Luciferin potassium salt is the substrate of luciferases that catalyze the production of light in bioluminescent insects.
3,4-Diaminofurazan 结构式
BCP00227 3,4-二氨基呋扎 17220-38-1
3,4-Diaminofurazan is a building block used to prepare magnesium and zinc alkynylated salicylaldehyde-diamine Schiff base complexes.
Eprenetapopt 结构式
BCP20294 Eprenetapopt 5291-32-7
APR-246 restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1Met also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance.
Temsirolimus 结构式
BCP25281 替西罗莫司 162635-04-3
Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay.
Vortioxetine 结构式
BCP05996 沃替西汀 508233-74-7
Vortioxetine (Lu AA21004) is an investigational novel antidepressant with multimodal activity that functions as a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter in vitro.
Favipiravir 结构式
BCP02422 法匹拉韦 259793-96-9
Favipiravir, also known as T705, is a RNA-directed RNA polymerase NS5B inhibitor
Repotrectinib 结构式
BCP19778 洛普替尼 1802220-02-5
TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.
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