LOXO-195
  • 化学数据
CAS号 2097002-61-2 货号 BCP20662
中文名 LOXO-195
英文名 LOXO-195
中文别名 赛利替尼;
英文别名 LOXO 195; LOXO195;Selitrectinib;
分子式 C20H21FN6O 分子量 380.43
  • 用途
生物活性 LOXO-195 is a potent and selective TRK inhibitor capable of addressing potential mechanisms of acquired resistance that may emerge in patients receiving larotrectinib (LOXO-101) or multikinase inhibitors with anti-TRK activity. LOXO-195 demonstrated potent inhibition of TRK fusions, including critical acquired resistance mutations, in enzyme and cellular assays, with minimal activity against other kinases. In diverse TRK fusion mouse models, LOXO-195 inhibited phospho-ERK and caused dramatic tumor growth inhibition, superior to first generation TRK inhibitors, without significant toxicity.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 Trk Receptor 

结构式

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