Sertraline

CAS No.	79617-96-2	Cat. No.	BCP26219
Name	Sertraline
Synonyms	Sealdin; Adjuvin; Atruline; CP 51,974-1; Cp-51,974-1; CP 51,974; CP51,974; CP-51,974; Gladem; Tatig; Tresleen; Zoloft;
Formula	C17H17Cl2N	M. Wt	306.23

Description	Sertraline is a selective serotonin uptake inhibitor that is used in the treatment of depression. Sertraline is primarily a serotonin reuptake inhibitor (SRI) with a binding affinity towards the serotonin transporter of Ki=2.8 nM or in that range. Sertraline is also a dopamine reuptake inhibitor, (<50 nmol/L). However, this is not considered a tight binding, and this action is only 10% of its potency as a monoamine reuptake inhibitor. It is a σ1 receptor agonist with 5% of its SRI potency, and an α1-adrenoreceptor antagonist with 1–10% of its SRI potency.
Pathways	Neuro Signaling Pathway
Targets	SSRI

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