石斛酚
| CAS号 | 67884-30-4 | 货号 | BCP29252 |
| 中文名 | 石斛酚 | ||
| 英文名 | Gigantol | ||
| 中文别名 | |||
| 英文别名 | Dendrophenol; | ||
| 分子式 | C16H18O4 | 分子量 | 274.31 |
| 生物活性 | Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-κB signaling pathway.Gigantol shows α-glucosidase inhibitory activity. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Wnt | ||
结构式
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