Chloral hydrate
| CAS No. | 302-17-0 | Cat. No. | BCP31225 |
| Name | Chloral hydrate | ||
| Synonyms | 2,2,2-Trichloroethane-1,1-diol;Trichloroacetaldehyde hydrate; | ||
| Formula | C2H3Cl3O2 | M. Wt | 165.4 |
| Description | Chloral Hydrate is a synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system. |
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Dexmedetomidine protects against endothelial injury in septic rats induced by cecal ligation and puncture by decreasing angiopoietin 2 and increasing vascular endothelial cadherin levels
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Structure
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