盐酸阿米替林
| CAS号 | 549-18-8 | 货号 | BCP31573 |
| 中文名 | 盐酸阿米替林 | ||
| 英文名 | Amitriptyline hydrochloride | ||
| 中文别名 | 阿米替林盐酸盐; | ||
| 英文别名 | Amitriptyline HCl;Nortriptyline Impurity F; | ||
| 分子式 | C20H23N.HCl | 分子量 | 313.87 |
| 生物活性 | Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | Sodium Channel | ||
结构式
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