Methyl leucylleucinate hydrochloride
| CAS号 | 6491-83-4 | 货号 | BCP31707 |
| 中文名 | Methyl leucylleucinate hydrochloride | ||
| 英文名 | Methyl leucylleucinate hydrochloride | ||
| 中文别名 | |||
| 英文别名 | L-Leucyl-L-Leucine methyl ester (hydrochloride);H-LEU-LEU-OME HCl;Leu-Leu-ome HCl; | ||
| 分子式 | C13H27ClN2O3 | 分子量 | 294.82 |
| 生物活性 | L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4 It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HIV | ||
结构式
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