Milademetan tosylate monohydrate
| CAS号 | 2095625-97-9 | 货号 | BCP31919 |
| 中文名 | Milademetan tosylate monohydrate | ||
| 英文名 | Milademetan tosylate monohydrate | ||
| 中文别名 | |||
| 英文别名 | DS3032b; DS-3032b; DS 3032b; DS3032; DS-3032; DS 3032; | ||
| 分子式 | C37H44Cl2FN5O8S | 分子量 | 808.74 |
| 生物活性 | Milademetan, also known as DS-3032b, is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Mdm2 | ||
结构式
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