Mavorixafor trihydrochloride

  • 化学数据
CAS号 2309699-17-8 货号 BCP32916
中文名 Mavorixafor trihydrochloride
英文名 Mavorixafor trihydrochloride
中文别名
英文别名 Mavorixafor 3HCl;AMD-070 trihydrochloride;AMD070 trihydrochloride;
分子式 C21H30Cl3N5 分子量 458.86
  • 用途
生物活性 Mavorixafor is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas.
上下游产品 558447-26-0(Mavorixafor) 880549-30-4(Mavorixafor hydrochloride)
信号通路 GPCR/G Protein 
靶 点 CXCR 

结构式

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