GS441524

  • Chemical Properties
CAS No. 1191237-69-0 Cat. No. BCP35590
Name GS441524
Synonyms GS-441524; GS 441524;Remdesivir-metabolite;GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite;
Formula C12H13N5O4 M. Wt 291.26
  • Biological Activity
Description GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir.
Pathways Microbiology/Virology Cell Cycle/DNA Damage 
Targets DNA/RNA Synthesis SARS CoV 
  • Publications Citing
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models

Publications Citing of Biochempartner's GS441524(CAS:1191237-69-0)

Structure

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