GS441524
| CAS号 | 1191237-69-0 | 货号 | BCP35590 |
| 中文名 | GS441524 | ||
| 英文名 | GS441524 | ||
| 中文别名 | 瑞德西韦中间体; | ||
| 英文别名 | GS-441524; GS 441524;Remdesivir-metabolite;GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite; | ||
| 分子式 | C12H13N5O4 | 分子量 | 291.26 |
| 生物活性 | GS-441524 is a potent inhibitor of feline infectious peritonitis (FIP) virus with an EC50 of 0.78 μM. GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM. Note: GS-441524 is an active metabolite of Remdesivir. | ||
| 信号通路 | Microbiology/Virology Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis SARS CoV | ||
|
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
购于瀚香生物(Biochempartner)的GS441524(CAS:1191237-69-0)被引用 |
结构式
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