Enfortumab
CAS No. | 1346452-25-2 | Cat. No. | BCP40770 |
Name | Enfortumab | ||
Synonyms | |||
Formula | M. Wt |
Description | Enfortumab vedotin is an antibody-drug conjugate comprised of multiple components.It contains a fully human monoclonal antibody directed against Nectin-4, an extracellular adhesion protein which is highly expressed in urothelial cancers,attached to a chemotherapeutic microtubule-disrupting agent, monomethyl auristatin E (MMAE). These two components are joined via a protease-cleavable linker. Enfortumab vedotin binds to cells expressing Nectin-4 and the resulting enfortumab-Nectin-4 complex is internalized into the cell. Once inside the cell, MMAE is released from enfortumab vedotin via proteolytic cleavage and goes on to disrupt the microtubule network within the cell, arresting the cell cycle and ultimately inducing apoptosis. |
Structure
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