ABC99
| CAS号 | 2331255-53-7 | 货号 | BCP47152 |
| 中文名 | ABC99 | ||
| 英文名 | ABC99 | ||
| 中文别名 | |||
| 英文别名 | ABC-99; ABC 99; | ||
| 分子式 | C22H21ClN4O5 | 分子量 | 456.88 |
| 生物活性 | ABC99 is a Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme, ABC99 inhibited NOTUM with an IC50 value of 13 nM and showed excellent selectivity across the serine hydrolase family, as initially assessed by gel-based ABPP of soluble and membrane proteomes from SW620 cells. ABC99 preserves Wnt-mediated cell signaling in the presence of NOTUM and was also converted into an ABPP probe for visualizing NOTUM in native biological systems. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Wnt | ||
结构式
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