Brigimadlin
  • 化学数据
CAS号 2095116-40-6 货号 BCP49630
中文名 Brigimadlin
英文名 Brigimadlin
中文别名
英文别名 BI 907828;BI 907828;BI 907828;
分子式 C31H25Cl2FN4O3 分子量 591.46
  • 用途
生物活性 Brigimadlin is an orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors.
信号通路 Apoptosis Pathway 
靶 点 Mdm2 

结构式

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