SC514
| CAS No. | 354812-17-2 | Cat. No. | BCP21098 |
| Name | SC514 | ||
| Synonyms | SC-514; SC 514;GK 01140;GK01140;GK-01140; | ||
| Formula | C9H8N2OS2 | M. Wt | 224.30 |
| Description | SC514 is a selective and reversible inhibitor of IκB kinase 2 (IKK2) (IC50 = 3-12 μM). SC-514 a candidate compound targeting osteoclastogenesis. SC-514 dose-dependently inhibits RANKL-induced osteoclastogenesis with an IC50 of <5μM. At high concentrations, SC-514 (≥12.5μM) induced apoptosis and caspase 3 activation in RAW264.7 cells. Targeting IKKβ by SC-514 presents as a potential treatment for osteoclast-related disorders such as osteoporosis and cancer-induced bone loss. | ||
| Pathways | NFκB | ||
| Targets | IκB/IKK | ||
Structure
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