Tezacaftor

  • Chemical Properties
CAS No. 1152311-62-0 Cat. No. BCP07173
Name Tezacaftor
Synonyms VX 661; VX661;VX-661;
Formula C26H27F3N2O6 M. Wt 520.5
  • Biological Activity
Description VX-661 is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of Δ508CFTR and partially restore chloride channel activity.
Pathways Ion Channel/Membrane Transporter 
Targets CFTR 

Structure

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