替扎卡托
| CAS号 | 1152311-62-0 | 货号 | BCP07173 |
| 中文名 | 替扎卡托 | ||
| 英文名 | Tezacaftor | ||
| 中文别名 | |||
| 英文别名 | VX 661; VX661;VX-661; | ||
| 分子式 | C26H27F3N2O6 | 分子量 | 520.5 |
| 生物活性 | VX-661 is CFTR modulator. VX-661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, Δ508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX-661 can correct trafficking of Δ508CFTR and partially restore chloride channel activity. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | CFTR | ||
结构式
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