伯森坦
| CAS号 | 147536-97-8 | 货号 | BCP05202 |
| 中文名 | 伯森坦 | ||
| 英文名 | Bosentan | ||
| 中文别名 | 波生坦; | ||
| 英文别名 | |||
| 分子式 | C27H29N5O6S | 分子量 | 551.61 |
| 生物活性 | Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Endothelin Receptor | ||
结构式
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