盐酸氨溴索
| CAS号 | 23828-92-4 | 货号 | BCP04490 |
| 中文名 | 盐酸氨溴索 | ||
| 英文名 | Ambroxol hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Ambroxol HCl;NA-872; NA872; NA 872; | ||
| 分子式 | C13H19Br2ClN2O | 分子量 | 414.56 |
| 生物活性 | Ambroxol inhibits Na+ channels in sensory neurons. The potency for tonic block of TTX-r channels is relatively high. Ambroxol affects the Na+ current kinetics of TTX-r and TTX-s channels differently. In CNaIIA cells, the compound behaves like a charged local anesthetic: the block is dependent on stimulus number and increases with higher frequencies in a train of depolarizing stimuli. In CNaIIA cells, ambroxol inhibits inactivated channels 5.5-fold more potently than resting channels. The corresponding factor for TTX-r channels is only 3.3.Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Others | ||
结构式
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