Vismodegib
| CAS No. | 879085-55-9 | Cat. No. | BCP01715 |
| Name | Vismodegib | ||
| Synonyms | GDC-0449;GDC 0449;GDC0449; RG3616; RG 3616; RG-3616; | ||
| Formula | C19H14Cl2N2O3S | M. Wt | 421.31 |
| Description | Vismodegib, also known as GDC-0449 or RG3616, is a hedgehog antagonist, is also a n orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Hedgehog | ||
|
Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production
Publications Citing of Biochempartner's Vismodegib(CAS:879085-55-9) |
|
Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia
Publications Citing of Biochempartner's Vismodegib(CAS:879085-55-9) |
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.