ICG-001
| CAS号 | 847591-62-2 | 货号 | BCP02465 |
| 中文名 | ICG-001 | ||
| 英文名 | ICG-001 | ||
| 中文别名 | |||
| 英文别名 | ICG 001; ICG001;PRI-724;PRI724; PRI 724; ICG001 isomer; ICG-001 isomer; ICG 001 isomer; | ||
| 分子式 | C33H32N4O4 | 分子量 | 548.63 |
| 生物活性 | PRI-724, an isomer or enantiomer of ICG-001, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. Note: ICG-001 and PRR-724 are not the same molecule, which are enantiomer isomers. Many vendors confused them. | ||
| 上下游产品 | 1422253-38-0（PRI-724） 780757-88-2（ICG-001） | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Beta catenin Wnt | ||
结构式
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