依伐卡托
| CAS号 | 873054-44-5 | 货号 | BCP01857 |
| 中文名 | 依伐卡托 | ||
| 英文名 | Ivacaftor | ||
| 中文别名 | |||
| 英文别名 | VX-770;VX770;VX 770;Kalydeco; | ||
| 分子式 | C24H28N2O3 | 分子量 | 392.49 |
| 生物活性 | Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel will be open and allow chloride ions pass through the channel pore. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | CFTR | ||
结构式
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