Sparsentan
| CAS号 | 254740-64-2 | 货号 | BCP23969 |
| 中文名 | Sparsentan | ||
| 英文名 | Sparsentan | ||
| 中文别名 | |||
| 英文别名 | RE-021; RE021; RE 021; PS-433540; PS 433540; DARA-a; | ||
| 分子式 | C32H40N4O5S | 分子量 | 592.75 |
| 生物活性 | Sparsentan is a Dual angiotensin II and endothelin A receptor antagonist. Retrophin intends to develop RE-021 for orphan indications of severe kidney diseases including Focal Segmental Glomerulosclerosis (FSGS) as well as conduct proof-of-concept studies in resistant hypertension and diabetic nephropathy. RE-021, with its unique dual blockade of angiotensin and endothelin receptors, is expected to provide meaningful clinical benefits in mitigating proteinuria in indications where there are no approved therapies. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Angiotensin Receptor Endothelin Receptor | ||
结构式
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