Vilaprisan
  • 化学数据
CAS号 1262108-14-4 货号 BCP24069
中文名 Vilaprisan
英文名 Vilaprisan
中文别名
英文别名 BAY1002670; BAY-1002670; BAY 1002670; BAY-10-02670; BAY10-02670; BAY 10-02670;
分子式 C27H29F5O4S 分子量 544.58
  • 用途
生物活性 Vilaprisan, also known as BAY1002670 or BAY10-02670, is a potent and selective oral progesterone receptor modulator that holds the promises of long-term treatment of patients with symptomatic uterine fibroids. BAY1002670 in subnanomolar concentrations exhibits a highly selective binding profile and antagonistic activity for the PR. These properties are also reflected in its action in two progesterone-dependent animal models that assess the termination of pregnancy and endometrial transformation. In a human fibroid xenograft model BAY 1002670 showed a marked dose-dependent reduction of fibroid tumour weight gain of 95% at a dose of 3 mg/kg/day (P < 0.005).
信号通路 Hormone Pathay 
靶 点 Progesterone Receptor 

结构式

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