ONT093
| CAS号 | 216227-54-2 | 货号 | BCP24637 |
| 中文名 | ONT093 | ||
| 英文名 | ONT093 | ||
| 中文别名 | |||
| 英文别名 | ONT-093; ONT 093; OC-144-093; OC 144-093; OC144-093; OC-144093; OC 144093; OC144093; Benzenamine; | ||
| 分子式 | C32H38N4O | 分子量 | 494.67 |
| 生物活性 | ONT-093, also known as OC-144-093, is an orally bioavailable P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics. OC144-093 is the least non-specifically toxic Pgp inhibitor described to date, with an average cytostatic IC50 of >60 microM in 15 cell types. OC144-093 may represent an ideal candidate for use in enhancement of AED blood-brain barrier penetration. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | P glycoprotein | ||
结构式
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