Alrizomadlin
| CAS号 | 1818393-16-6 | 货号 | BCP25148 |
| 中文名 | Alrizomadlin | ||
| 英文名 | Alrizomadlin | ||
| 中文别名 | |||
| 英文别名 | AA 115; AA115; APG 115; APG115; APG-115;AA-115; | ||
| 分子式 | C34H38Cl2FN3O4 | 分子量 | 642.59 |
| 生物活性 | Alrizomadlin is an orally available inhibitor of human homolog of double minute 2 (HDM2; mouse double minute 2 homolog; MDM2), with potential antineoplastic activity. Upon oral administration,alrizomadlin binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Mdm2 | ||
结构式
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