Eprenetapopt
| CAS号 | 5291-32-7 | 货号 | BCP20294 |
| 中文名 | Eprenetapopt | ||
| 英文名 | Eprenetapopt | ||
| 中文别名 | |||
| 英文别名 | APR-246;APR 246;APR246;Prima-1met; | ||
| 分子式 | C10H17NO3 | 分子量 | 199 |
| 生物活性 | APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. p53 activator APR-246 binds to and activates transcription of the Wrap53 gene, which results in an increase in WRAP53 p53 antisense transcript levels and, potentially, an increase in native p53 activity; in turn, increased p53 activity may lead to an induction of cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | p53 | ||
结构式
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