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GNE-490 Chemical Structure

GNE-490

Data Sheet For research use only. Not for human use.
Cat. No. :BCP21623CAS No. :1033739-92-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1033739-92-2 Cat. No. BCP21623
Name GNE-490
Synonyms GNE490;GNE 490;
SMILES OC(C)(C)C1=CC2=C(S1)C(N3CCOCC3)=NC(C4=C(C)N=C(N)N=C4)=N2
Chemical Name
Formula C18H22N6O2S M. Wt 386.47
Purity 98% Storage Store at 4-8°C
Description GNE-490 is a highly selective pan-PI3K inhibitor that demonstrates selectivity over mTOR. It has good pharmacokinetic (PK) parameters and demonstrates knock down of pathway markers in vivo. Originally obtained via modification of compounds like GDC-0941, GNE-490 which have a significantly reduced potency mTOR while maintaining effective potency for PI3K substrates. IC50 values for PI3K family members are in the subnanomolar to low nanomolar range (-.28 to <20nm) while IC50 values for mTOR and other related tyrosine kinases are greater than 750 nM with most being greater than 1 uM or more, thus GNE-490 makes a good choice for examining PI3K related events separate from those mediated by mTOR.
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