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Parsaclisib Chemical Structure

Parsaclisib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP33523CAS No. :1426698-88-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1426698-88-5 Cat. No. BCP33523
Name Parsaclisib
Synonyms INCB-50465; INCB 50465; IINCB050465; INCB-050465; INCB 050465;
SMILES CCOC1=C(C(=C(C=C1C(C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)C4CC(=O)NC4
Chemical Name
Formula C20H22ClFN6O2 M. Wt 432.88
Purity 98% Storage Store at 4-8°C
Description Parsaclisib, also known as INCB050465, is a novel PI3Kδ inhibitor which synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. INCB050465 inhibits PI3Kδ (IC50 = 1 nM at 1 mM ATP) with approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. INCB050465 demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM. In addition, INCB050465 blocks the proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM) and can slow tumor growth in the Pfeiffer model of DLBCL in vivo.
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