MAZ51 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP31595CAS No. ：163655-37-6Purity：98%

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CAS No.	163655-37-6	Cat. No.	BCP31595
Name	MAZ51
Synonyms	MAZ-51;MAZ 51;
SMILES	CN(C)C1=CC=C(C2=CC=CC=C21)C=C3C4=CC=CC=C4NC3=O
Chemical Name
Formula	C21H18N2O	M. Wt	314.38
Purity	98%	Storage	Store at 4-8°C
Description	MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.