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(S)-PF-04995274 Chemical Structure

(S)-PF-04995274

Data Sheet For research use only. Not for human use.
Cat. No. :BCP37093CAS No. :2170558-28-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 2170558-28-6 Cat. No. BCP37093
Name (S)-PF-04995274
Synonyms S- PF 04995274;PF 04995274;PF-04995274;PF04995274;
SMILES C1CN(CCC1COC2=NOC3=C2C(=CC=C3)OC4CCOC4)CC5(CCOCC5)O
Chemical Name
Formula C23H32N2O6 M. Wt 432.52
Purity 98% Storage Store at 4-8°C
Description PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S). PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.
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