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CAS号 | 2219320-08-6 | 货号 | BCP31488 |
中文名 | MSC1094308 | ||
英文名 | MSC1094308 | ||
中文别名 | |||
英文别名 | MSC-1094308; MSC 1094308; | ||
SMILES | FC1=CC=C(C(C2=CC=C(F)C=C2)CCCNCC3CCC(NC4=C5C=C(F)C=C4)=C5C3)C=C1 | ||
化学名称 | |||
分子式 | C29H29F3N2 | 分子量 | 462.55 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | MSC1094308 is a Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. MSC1094308 binds to a previously characterized drugable hotspot of p97, thereby inhibiting the D2 ATPase activity. Our results furthermore indicate that a similar allosteric site exists in VPS4B, suggesting conserved allosteric circuits and drugable sites in both type I and II AAA ATPases. Our results may thus guide future chemical tool and drug discovery efforts for the biomedically relevant AAA ATPases. |
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