GW806742X 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP29591CAS号：579515-63-2纯度：98%

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CAS号	579515-63-2	货号	BCP29591
中文名	GW806742X
英文名	GW806742X
中文别名
英文别名	GW-806742X;GW 806742X;MLKL compound 1;
SMILES	CN(C1=CC=C(C=C1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F)C3=NC(=NC=C3)NC4=CC(=CC=C4)S(=O)(=O)N
化学名称
分子式	C25H22F3N7O4S	分子量	573.55
纯度	98%	配送	惯例下常温包邮
产品描述	GW806742X is a nanomolar inhibitor of the protein kinase, VEGFR2 (2nm) and also binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis. With regards to its role in necroptosis, GW806742X is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited TSQ-induced death of mouse dermal fibroblasts by delaying MLKL translocation to the membrane. GW806742X therefore appears to be a valuable reagent to inhibit necroptosis. It also provides an important proof-of-principle that targeting catalytically-dead pseudoenzymes represents a feasible, emerging therapeutic avenue.