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Canagliflozin Chemical Structure

Canagliflozin

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02520CAS No. :842133-18-0Purity:98%
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  • Publications Citing of Biochempartner's Canagliflozin
  • Chemical Properties&Biological Activity
CAS No. 842133-18-0 Cat. No. BCP02520
Name Canagliflozin
Synonyms JNJ 24831754; JNJ24831754; JNJ-24831754; JNJ24831754AAA; JNJ24831754ZAE; TA 7284; TA-7284; TA7284;
SMILES CC1=C(C=C(C=C1)C2C(C(C(C(O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F
Chemical Name
Formula C24H25FO5S M. Wt 444.52
Purity 98% Storage Store at 4-8°C
Description Canagliflozin inhibits Na+-dependent 14C-AMG uptake in a concentration-dependent fashion. Canagliflozin inhibits 14C-AMG uptake in CHO-hSGLT1 and mSGLT1 cells with IC50 of 0.7 μM and >1 μM, respectively. Canagliflozin inhibits the facilitative (non-Na+-linked) GLUT-mediated 2H-2-DG uptake in L6 myoblasts by less than 50%. In sham-injected oocytes, Canagliflozin (10 μM) or phlorizin (3 mM) alone in the presence of 50 μM DNJ does not affect currents. In SGLT3-injected oocytes, DMSO and Canagliflozin 10 μM inhibits DNJ-induced currents by 15.6% and 23.4%, respectively.
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