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BGT226 Chemical Structure

BGT226

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP26216CAS No. ：915020-55-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 915020-55-2 Cat. No. BCP26216
Name BGT226
Synonyms BGT 226; BGT-226; NVP-BGT226; NVP-BGT-226; NVP-BGT 226;
SMILES CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC
Chemical Name
Formula C28H25F3N6O2 M. Wt 534.54
Purity 98% Storage Store at 4-8°C
Description BGT226 is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.
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