A bifunctional molecule-based strategy for the development of theranostic antibody-drug conjugate
Dian Xiao, Lei Zhao, Fei Xie, Shiyong Fan, Lianqi Liu, Wei Li, Ruiyuan Cao, Song Li, Wu Zhong,✉ and Xinbo Zhou
Theranostics. 2021; 11(6): 2550–2563.
PMID: 33456559 DOI: 10.7150/thno.51232
Antibody-drug conjugates (ADCs) are being developed worldwide with the potential to revolutionize current cancer treatment strategies. Developing novel theranostic ADCs with therapeutic utility and imaging capability is an attractive and challenging subject that promises advances in the field of personalized medicine. In this work, we propose a bifunctional molecule-based strategy for the development of theranostic ADCs.