BMS-779788
  • 化学数据
CAS号 918348-67-1 货号 BCP20751
中文名 BMS-779788
英文名 BMS-779788
中文别名
英文别名 BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652;
分子式 C28H29ClN2O3S 分子量 509.06
  • 用途
生物活性 BMS-779788, also known as XL-652, EXEL 04286652 and BMS-788, is potent partial LXR agonist with LXRβ selectivity, which has an improved therapeutic window in the cynomolgus monkey compared with a full pan agonist. BMS-779788 induced LXR target genes in blood in vivo with an EC50 = 610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 was 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B.
信号通路 Protease/Metabolic Enzyme 
靶 点 LXR 

结构式

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