Ensartinib

  • 化学数据
CAS号 1370651-20-9 货号 BCP26265
中文名 Ensartinib
英文名 Ensartinib
中文别名
英文别名 X396; X-396; X 396;
分子式 C25H25Cl2FN6O3 分子量 547.41
  • 用途
生物活性 Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met ALK 

结构式

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