恩沙替尼二盐酸盐
| CAS号 | 2137030-98-7 | 货号 | BCP29059 |
| 中文名 | 恩沙替尼二盐酸盐 | ||
| 英文名 | Ensartinib dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | X396; X-396; X 396;X-396 hydrochloride; | ||
| 分子式 | C26H29Cl4FN6O3 | 分子量 | 634.36 |
| 生物活性 | Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met ALK | ||
结构式
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