Ketohexokinase inhibitor 1
CAS号 | 2102501-84-6 | 货号 | BCP29373 |
中文名 | Ketohexokinase inhibitor 1 | ||
英文名 | Ketohexokinase inhibitor 1 | ||
中文别名 | |||
英文别名 | PF-06835919;PF06835919;PF 06835919;MDK1846;MDK-1846; MDK 1846;Ketohexokinase-In-1; | ||
分子式 | C16H19F3N4O2 | 分子量 | 356.34 |
生物活性 | Ketohexokinase inhibitor 1is a potent ketohexokinase (KHK) inhibitor. MDK1846 has CAS#2102501-84-6. The last 4 digit was used for naming for the convenience of scientific communication. MDK1846 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. | ||
信号通路 | Others Pathway | ||
靶 点 | Others |
结构式

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