HS1371
  • 化学数据
CAS号 2158197-70-5 货号 BCP30268
中文名 HS1371
英文名 HS1371
中文别名
英文别名 HS-1371；HS 1371;
分子式 C24H24N4O 分子量 384.48
  • 用途
生物活性 HS-1371 is a novel kinase inhibitor of RIP3-mediated necroptosis. HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner, providing a mechanism of action. Moreover, the compound inhibited TNF-induced necroptosis but did not inhibit TNF-induced apoptosis, indicating that this novel inhibitor has a specific inhibitory effect on RIP3-mediated necroptosis via the suppression of RIP3 kinase activity. HS-1371 could serve as a potential preventive or therapeutic agent for diseases involving RIP3 hyperactivation.
信号通路 Apoptosis Pathway 
靶 点 RIP 

结构式

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